Traditional Chinese Medicine (TCM) is a system of practices that has been developing for over 2,000 years. Unlike in medicine developed in western culture, it is characterized by a holistic approach to treat diseases, taking into account context of given disease (co-occurring diseases, age and sex of the patient). The practices of Traditional Chinese Medicine include acupuncture, acupressure, qigong gymnastics, and the application of herbal medicine and usage of medicinal mushrooms. According to WHO, cardiovascular diseases, such as stroke or heart attack, are one of leading causes of death, accounting for almost 1/3 of all deaths in 2019. Of the many mushrooms with medicinal properties, those that can be used as drugs for the treatment of cardiovascular diseases deserve special attention. This category includes, among others mushrooms from genus Agaricus, Auricularia or Pleurotus. They are rich source of bioactive compounds, such as flavonoids, sterols, polysaccharides and fiber. Among them, some mushrooms act in a direct way, e.g. by reducing atherosclerotic plaque, and some in an indirect manner, e.g. by reducing blood pressure and cholesterol levels. The main issues in the integration of TCM into Western medicine are the lack of sufficient evidence of its effectiveness, the poor quality of clinical trials, as well as the small number of publications available in English. In the case of mushrooms used in TCM, most studies were performed in animal models or cell lines and used only a single substance instead of the whole fungus.